Expectations from structural genomics

Expectations from structural genomics.

Structural genomics projects aim to provide an experimental structure or a good model for every protein in all completed genomes. Most of the experimental work for these projects will be directed toward proteins whose fold cannot be readily recognized by simple sequence comparison with proteins of known structure. Based on the history of proteins classified in the SCOP structure database, we ex...

The impact of structural genomics: expectations and outcomes.

Structural genomics (SG) projects aim to expand our structural knowledge of biological macromolecules while lowering the average costs of structure determination. We quantitatively analyzed the novelty, cost, and impact of structures solved by SG centers, and we contrast these results with traditional structural biology. The first structure identified in a protein family enables inference of th...

Structural genomics

theory, based on the shape and location of coral formations, on coral’s inability to grow at depths greater than 30 fathoms, and most of all on a scenario for which he had no evidence: that each reef or atoll represents the outer limit of an island that has slowly subsided into the ocean. Read this chapter, if only to be struck by its masterly fusion of acute observation and trenchant imaginati...

Genomics Research and Malaria Control: Great Expectations

PLoS Biology | http://biology.plosjournals.org The protozoan parasite Plasmodium falciparum causes falciparum malaria, a fatal parasitic disease in humans, and is transmitted by Anopheles mosquito vectors (predominantly the Anopheles gambiae complex and An. funestus in Africa). There are about 300 million malaria cases and 1–2 million deaths annually, the brunt of which are borne mostly in Afri...

Bioinformatics in structural genomics.